Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects

Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects

Abstract Background Clinically, for stem cell-based therapy (SCBT), autologous stem cells are considered better than allogenic stem cells because of little immune rejection and no risk of communicable disease infection. However, severe maxillofacial bone defects restoration needs sufficient autologo...

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Bibliographic Details
Main Authors: Anyuan Shi, Aerali Heinayati, Dongyu Bao, Huifen Liu, Xiaochen Ding, Xin Tong, Liudi Wang, Bin Wang, Haiyan Qin
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Subjects:
GMSCs
SB431542
TGF-β signaling
Osteogenic differentiation
BMP
Bone defect
Online Access:http://link.springer.com/article/10.1186/s13287-019-1281-2

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http://link.springer.com/article/10.1186/s13287-019-1281-2

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