A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

N6-methyladenosine (m6A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but the underlying regulatory mechanisms remain elusive. Here, we identify...

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Bibliographic Details
Main Authors: Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
METTL3
methyltransferase complex
m6A methylation
breast tumorigenesis
MTC
Online Access:https://elifesciences.org/articles/87283

Internet

https://elifesciences.org/articles/87283

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