Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.

Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.

Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying immunoreceptor tyrosine based inhibitory motifs (ITIMs) and delivering inhibitory signals upon ligation with sialylated glycans. This inhibitory function can be also targeted by several pathogens that h...

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Bibliographic Details
Main Authors: Stefania Varchetta, Enrico Brunetta, Alessandra Roberto, Joanna Mikulak, Kelly L Hudspeth, Mario U Mondelli, Domenico Mavilio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029261/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029261/?tool=EBI

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