Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment

Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment

Summary: Background: Globally, the tuberculosis (TB) treatment success rate is approximately 85%, with treatment failure, relapse and death occurring in a significant proportion of pulmonary TB patients. Treatment success is lower among people with diabetes mellitus (DM). Predicting treatment outco...

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Main Authors: Cassandra L.R. van Doorn, Clare Eckold, Katharina Ronacher, Rovina Ruslami, Suzanne van Veen, Ji-Sook Lee, Vinod Kumar, Sarah Kerry-Barnard, Stephanus T. Malherbe, Léanie Kleynhans, Kim Stanley, Philip C. Hill, Simone A. Joosten, Reinout van Crevel, Cisca Wijmenga, Julia A. Critchley, Gerhard Walzl, Bachti Alisjahbana, Mariëlle C. Haks, Hazel M. Dockrell, Tom H.M. Ottenhoff, Eleonora Vianello, Jacqueline M. Cliff
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Biomarkers
Tuberculosis
Treatment outcome
Diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003541

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http://www.sciencedirect.com/science/article/pii/S2352396422003541

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