MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer

MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer

Abstract Background The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marker of plexiform fibromyxoma and gastroblastoma; however, the function...

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Bibliographic Details
Main Authors: Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimoto
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Cancer
Subjects:
MALAT1
GLI1
MALAT1::GLI1 fusion gene
Plexiform fibromyxoma
5' RACE
Luciferase assay
Online Access:https://doi.org/10.1186/s12885-023-10867-6

Internet

https://doi.org/10.1186/s12885-023-10867-6

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