Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar Typhimurium Braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar Typhimurium Braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

We evaluated the extent of attenuation and immunogenicity of the ∆lppAB and ∆lppAB ∆msbB mutants of Salmonella enterica serovar Typhimurium when delivered to mice by the oral route. These mutants were deleted either for the Braun lipoprotein genes (lppA and lppB) or in combination with the msbB gene...

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Bibliographic Details
Main Authors: Tatiana E Erova, Michelle L Kirtley, Erc C Fitts, Duraisamy Ponnusamy, Wallace B Baze, Jourdan A Andersson, Yingzi Cong, Bethany L Tiner, Jian Sha, Ashok K Chopra
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
lipopolysaccharide (LPS)
Salmonella enterica serovar Typhimurium
innate and adaptive immune responses
mouse model of salmonellosis
Braun or murein lipoprotein (Lpp)
acetyltransferase (MsbB)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00148/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00148/full

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