A Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling

A Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling

The current anti-cancer treatments are not enough to eradicate tumors, and therefore, new modalities and strategies are still needed. Most tumors generate an inflammatory tumor microenvironment (TME) and maintain the niche for their development. Because of the critical role of inflammation via high-...

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Bibliographic Details
Main Authors: Sei-ichi Tanuma, Takahiro Oyama, Miwa Okazawa, Hiroaki Yamazaki, Koichi Takao, Yoshiaki Sugita, Shigeru Amano, Takehiko Abe, Hiroshi Sakagami
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
inflammation
tumor microenvironment
carcinogenesis
receptor for advanced glycation end-products
high-mobility group box 1
extracellular signal-regulated kinases 1 and 2
Online Access:https://www.mdpi.com/1422-0067/23/7/3426

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https://www.mdpi.com/1422-0067/23/7/3426

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