Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1–NF-κB Pathway

Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1–NF-κB Pathway

Macrophages, characterized by considerable diversity and plasticity, play a crucial role in a broad spectrum of biological processes, including inflammation. However, the molecular mechanisms underlying the diverse phenotypes of macrophages are not well defined. Here, we show that the RNA-binding pr...

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Bibliographic Details
Main Authors: Li Wang, Dong-Sheng Zhai, Ban-Jun Ruan, Cheng-Ming Xu, Zi-Chen Ye, Huan-Yu Lu, Ying-Hao Jiang, Zhen-Yu Wang, An Xiang, Yuan Yang, Jian-Lin Yuan, Zi-Fan Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
quaking
macrophage polarization
endotoxemia
aryl hydrocarbon receptor
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01754/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01754/full

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