Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

Abstract Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in patients with COVID-19. To address these questions, we analyzed the metabolome of ne...

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Bibliographic Details
Main Authors: Yafeng Li, Jessica S. Hook, Qing Ding, Xue Xiao, Stephen S. Chung, Marcel Mettlen, Lin Xu, Jessica G. Moreland, Michalis Agathocleous
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37567-w