Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment

Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment

Abstract Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induction of nerve growth factor (NGF) by the t...

Full description

Bibliographic Details
Main Authors: Sam W. Z. Olechnowicz, Megan M. Weivoda, Seint T. Lwin, Szi K. Leung, Sarah Gooding, Guido Nador, Muhammed Kassim Javaid, Karthik Ramasamy, Srinivasa R. Rao, James R. Edwards, Claire M. Edwards
Format: Article
Language:English
Published: Nature Portfolio 2019-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-50591-5

Internet

https://doi.org/10.1038/s41598-019-50591-5

Similar Items