Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2

Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2

Human lysosomal acid lipase (LAL) is a hydrolase required for the cleavage of cholesteryl esters and triglycerides derived from plasma lipoproteins. It is shown here that during monocyte to macrophage differentiation, the expression of LAL-mRNA is induced. This induction is dependent on protein kina...

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Bibliographic Details
Main Authors: Stefan Ries, Christa Büchler, Thomas Langmann, Petra Fehringer, Charalampos Aslanidis, Gerd Schmitz
Format: Article
Language:English
Published: Elsevier 1998-11-01
Series:Journal of Lipid Research
Subjects:
cholesterol metabolism
acid lipase
lysosome
macrophage
differentiation
LAL-promoter
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324676

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http://www.sciencedirect.com/science/article/pii/S0022227520324676

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