Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells

Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells

The development of efficient cell culture strategies for the generation of dopaminergic neurons is an important goal for transplantation-based approaches to treat Parkinson’s disease. To identify extracellular matrix molecules that enhance differentiation and might be used in these cell cultures we...

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Bibliographic Details
Main Authors: Maqsood Ahmed, Matthew J. S. Owens, Enrique M. Toledo, Ernest Arenas, Mark Bradley, Charles ffrench-Constant
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular matrix
neural stem cells
tyrosine hydroxylase
matricellular proteins
dopaminergic (DA) neuron
array
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.755406/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.755406/full

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