50nm-scale localization of single unmodified, isotopically enriched, proteins in cells.

50nm-scale localization of single unmodified, isotopically enriched, proteins in cells.

Imaging single proteins within cells is challenging if the possibility of artefacts due to tagging or to recognition by antibodies is to be avoided. It is generally believed that the biological properties of proteins remain unaltered when (14)N isotopes are replaced with (15)N. (15)N-enriched protei...

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Bibliographic Details
Main Authors: Anthony Delaune, Armelle Cabin-Flaman, Guillaume Legent, David Gibouin, Caroline Smet-Nocca, Fabrice Lefebvre, Arndt Benecke, Marc Vasse, Camille Ripoll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3576336?pdf=render

Internet

http://europepmc.org/articles/PMC3576336?pdf=render

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