Syntheses and Structure–Activity Relationships of <i>N</i>-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome <i>bd</i> Oxidase in <i>Mycobacterium tuberculosis</i>

Syntheses and Structure–Activity Relationships of <i>N</i>-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome <i>bd</i> Oxidase in <i>Mycobacterium tuberculosis</i>

The development of cytochrome <i>bd</i> oxidase (cyt-<i>bd</i>) inhibitors are needed for comprehensive termination of energy production in <i>Mycobacterium tuberculosis</i> (Mtb) to treat tuberculosis infections. Herein, we report on the structure-activity-relati...

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Bibliographic Details
Main Authors: Sarah M. Hopfner, Bei Shi Lee, Nitin P. Kalia, Marvin J. Miller, Kevin Pethe, Garrett C. Moraski
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Applied Sciences
Subjects:
tuberculosis
drug development
structure–activity relationships
quinazoline
energy metabolism
cytochrome <i>bd</i> oxidase
Online Access:https://www.mdpi.com/2076-3417/11/19/9092

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https://www.mdpi.com/2076-3417/11/19/9092

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