Aberrant HIF1- α and SIX-1 Expression is Associated with Poor Prognosis in Acute Myeloid Leukemia Patients with Isocitrate Dehydrogenase 1 Mutations

Aberrant HIF1- α and SIX-1 Expression is Associated with Poor Prognosis in Acute Myeloid Leukemia Patients with Isocitrate Dehydrogenase 1 Mutations

Background IDH1 mutations are common in many cancers, however, their role in promoting the Warburg effect remains elusive. This study elucidates the putative involvement of mutant-IDH1 in regulating hypoxia-inducible factor (HIF1-α) and Sine-Oculis Homeobox-1 (SIX-1) expression. Methodology Genetic...

Full description

Bibliographic Details
Main Authors: Tariq Ali MS, Rohma Usman MS, Syed Alasar Shah MS, Aamir Parvez MD, Summayya Anwar MS, Zahid Muneer PhD, Muhammad Saeed PhD
Format: Article
Language:English
Published: SAGE Publishing 2024-07-01
Series:Cancer Control
Online Access:https://doi.org/10.1177/10732748241271714

Internet

https://doi.org/10.1177/10732748241271714

Similar Items