Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background

We generated constitutive knockout mouse models for the α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits by derivation from conditional knockouts by breeding with CRE deleter mice. We then backcrossed them onto a C57BL/6J genetic background. In this manuscript, we report the generation o...

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Bibliographic Details
Main Authors: Barbara J. Morley, David F. Dolan, Kevin K. Ohlemiller, Dwayne D. Simmons
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00516/full