A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

Abstract DNA damage contributes to atherosclerosis. However, causative links between DNA double-strand breaks (DSBs) and atherosclerosis have yet to be established. Here, we investigated the role of DSBs in atherosclerosis using mice and vascular cells deficient in Ku80, a DSB repair protein. After...

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Bibliographic Details
Main Authors: Chiemi Sakai, Keitaro Ueda, Kohei Goda, Rikuto Fujita, Junji Maeda, Shinya Nakayama, Yusuke Sotomaru, Satoshi Tashiro, Masao Yoshizumi, Takafumi Ishida, Mari Ishida
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43848-7

Internet

https://doi.org/10.1038/s41598-023-43848-7

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