Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy

Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy

Introduction: Hypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes that increase myocyte energy demand and lead to cardiac hypertrophy. However, it is unknown whether a common metabolic trait underlies cardiac phenotype at the early disease stage. To address...

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Bibliographic Details
Main Authors: Arpana Vaniya, Anja Karlstaedt, Damla Gulkok, Tilo Thottakara, Yamin Liu, Sili Fan, Hannah Eades, Styliani Vakrou, Ryuya Fukunaga, Hilary J. Vernon, Oliver Fiehn, M. Roselle Abraham
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Untargeted metabolomics
Lipidomics
Hypertrophic cardiomyopathy
RNAseq
HCM mouse models
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976124000138

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http://www.sciencedirect.com/science/article/pii/S2772976124000138

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