Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases

Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases

In the field of drug discovery, the nitrile group is well represented among drugs and biologically active compounds. It can form both non-covalent and covalent interactions with diverse biological targets, and it is amenable as an electrophilic warhead for covalent inhibition. The main advantage of...

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Bibliographic Details
Main Authors: Simone Brogi, Roberta Ibba, Sara Rossi, Stefania Butini, Vincenzo Calderone, Sandra Gemma, Giuseppe Campiani
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
nitrile
warhead
cysteine/serine/threonine protease
virus
protozoan parasite
covalent inhibition
Online Access:https://www.mdpi.com/1420-3049/27/8/2561

Internet

https://www.mdpi.com/1420-3049/27/8/2561

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