Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome

Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome

Abstract Background Heparan sulfate (HS) degradation mediates pulmonary endothelial hyper-permeability and acute pulmonary edema during acute respiratory distress syndrome (ARDS). The aim of this study was to examine whether histone H4 induced HS degradation by activating heparanase (HPSE) in chlori...

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Bibliographic Details
Main Authors: Yanlin Zhang, Fei Xu, Li Guan, Ming Chen, Yiran Zhao, Lixia Guo, Xiao Li, Yimu Zheng, Ai Gao, Shuqiang Li
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Respiratory Research
Subjects:
Acute respiratory distress syndrome
Endothelium
Inflammation
Heparan sulfate
Heparanase
Extracellular histones
Online Access:https://doi.org/10.1186/s12931-022-01932-y

Internet

https://doi.org/10.1186/s12931-022-01932-y

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