Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy

AMP-activated protein kinase (AMPK) is a crucial metabolic regulator with profound modulatory activities on inflammation. Although the anti-inflammatory benefits of AMPK activators were well documented in experimental studies, the pathological significance of endogenous AMPK in inflammatory disorder...

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Bibliographic Details
Main Authors: Kerui Fan, Ling Lin, Qing Ai, Jingyuan Wan, Jie Dai, Gang Liu, Li Tang, Yongqiang Yang, Pu Ge, Rong Jiang, Li Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
AMP-activated protein kinase
lipopolysaccharide
autophagy
mammalian target of rapamycin
uncoordinated-51-like kinase 1
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01464/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01464/full

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