IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor?
The role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumour...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00025/full |
| _version_ | 1828869472540164096 |
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| author | Adam ePickard Dennis J McCance Dennis J McCance |
| author_facet | Adam ePickard Dennis J McCance Dennis J McCance |
| author_sort | Adam ePickard |
| collection | DOAJ |
| description | The role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumour suppressor manner. In this mini-review we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings. |
| first_indexed | 2024-12-13T05:50:59Z |
| format | Article |
| id | doaj.art-d8da6e1282834415994d5690ec645326 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T05:50:59Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d8da6e1282834415994d5690ec6453262022-12-21T23:57:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922015-02-01610.3389/fendo.2015.00025134460IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor?Adam ePickard0Dennis J McCance1Dennis J McCance2Queen's University BelfastQueen's University BelfastUniversity of New MexicoThe role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumour suppressor manner. In this mini-review we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00025/fullOncogenesIGF-1IGF-Itumour suppressorIGFBPsIGF-II |
| spellingShingle | Adam ePickard Dennis J McCance Dennis J McCance IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? Frontiers in Endocrinology Oncogenes IGF-1 IGF-I tumour suppressor IGFBPs IGF-II |
| title | IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? |
| title_full | IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? |
| title_fullStr | IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? |
| title_full_unstemmed | IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? |
| title_short | IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor? |
| title_sort | igf binding protein 2 igfbp2 oncogene or tumour suppressor |
| topic | Oncogenes IGF-1 IGF-I tumour suppressor IGFBPs IGF-II |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00025/full |
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