Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes

The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies in IgG-mediated autoimmune diseases. In epith...

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Bibliographic Details
Main Authors: Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
autoimmune diseases
autoantibodies
bullous skin diseases
pemphigus
neonatal Fc receptor
Fc fragment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473637/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473637/full

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