αvβ3 Integrin induces partial EMT independent of TGF-β signaling
Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02003-6 |
| _version_ | 1818435068513746944 |
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| author | Yoshinobu Kariya Midori Oyama Takato Suzuki Yukiko Kariya |
| author_facet | Yoshinobu Kariya Midori Oyama Takato Suzuki Yukiko Kariya |
| author_sort | Yoshinobu Kariya |
| collection | DOAJ |
| description | Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, stemness and metastatic capacity. |
| first_indexed | 2024-12-14T16:47:00Z |
| format | Article |
| id | doaj.art-d8dded810a1f4dd2ba943cbec8b2bb05 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T16:47:00Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d8dded810a1f4dd2ba943cbec8b2bb052022-12-21T22:54:09ZengNature PortfolioCommunications Biology2399-36422021-04-014111110.1038/s42003-021-02003-6αvβ3 Integrin induces partial EMT independent of TGF-β signalingYoshinobu Kariya0Midori Oyama1Takato Suzuki2Yukiko Kariya3Department of Biochemistry, Fukushima Medical University School of MedicineDepartment of Biochemistry, Fukushima Medical University School of MedicineLaboratory Animal Research Center, Fukushima Medical University School of MedicineDepartment of Biochemistry, Fukushima Medical University School of MedicineKariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, stemness and metastatic capacity.https://doi.org/10.1038/s42003-021-02003-6 |
| spellingShingle | Yoshinobu Kariya Midori Oyama Takato Suzuki Yukiko Kariya αvβ3 Integrin induces partial EMT independent of TGF-β signaling Communications Biology |
| title | αvβ3 Integrin induces partial EMT independent of TGF-β signaling |
| title_full | αvβ3 Integrin induces partial EMT independent of TGF-β signaling |
| title_fullStr | αvβ3 Integrin induces partial EMT independent of TGF-β signaling |
| title_full_unstemmed | αvβ3 Integrin induces partial EMT independent of TGF-β signaling |
| title_short | αvβ3 Integrin induces partial EMT independent of TGF-β signaling |
| title_sort | αvβ3 integrin induces partial emt independent of tgf β signaling |
| url | https://doi.org/10.1038/s42003-021-02003-6 |
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