Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations.

Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations.

Our previous studies indicated that recombinant rabies viruses (rRABV) expressing chemokines or cytokines (including GM-CSF) could enhance the immunogenicity by recruiting and/or activating dendritic cells (DC). In this study, bacterial flagellin was cloned into the RABV genome and recombinant virus...

Full description

Bibliographic Details
Main Authors: Ming Zhou, Guoqing Zhang, Guiping Ren, Clement W Gnanadurai, Zhenguang Li, Qingqing Chai, Yang Yang, Christina M Leyson, Wenxue Wu, Min Cui, Zhen F Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3658976?pdf=render

Internet

http://europepmc.org/articles/PMC3658976?pdf=render

Similar Items