Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Abstract Background Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated. Methods We investigated this in two patient-derived xenografts (PDXs) developed from breast-to-bone metasta...

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Bibliographic Details
Main Authors: Razan Wafai, Elizabeth D. Williams, Emma de Souza, Peter T. Simpson, Amy E. McCart Reed, Jamie R. Kutasovic, Mark Waltham, Cameron E. Snell, Tony Blick, Erik W. Thompson, Honor J. Hugo
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Breast Cancer Research
Subjects:
Integrin
Hypoxia
Twist1
EMT
Breast cancer
Patient-derived xenograft (PDX)
Online Access:https://doi.org/10.1186/s13058-020-01366-8

Internet

https://doi.org/10.1186/s13058-020-01366-8

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