An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress

TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant TDP-43 are expressed at low levels and where alte...

Full description

Bibliographic Details
Main Authors: Emily Feneberg, David Gordon, Alexander G. Thompson, Mattéa J. Finelli, Ruxandra Dafinca, Ana Candalija, Philip D. Charles, Imre Mäger, Matthew J. Wood, Roman Fischer, Benedikt M. Kessler, Elizabeth Gray, Martin R. Turner, Kevin Talbot
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
TDP-43
Neurodegeneration
Oxidative stress
Interactome
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303259

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120303259

Similar Items