LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait. Hamsters, like humans, have the cholesteryl ester transfer protein, intestine-onl...

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Bibliographic Details
Main Authors: Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:EBioMedicine
Subjects:
LDL receptor
Golden Syrian hamster
Hyperlipidemia
Atherosclerosis
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304942

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http://www.sciencedirect.com/science/article/pii/S2352396417304942

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