Serum from morbidly obese patients affects melanoma cell behavior in vitro

Serum from morbidly obese patients affects melanoma cell behavior in vitro

Abstract Here we examined whether serum from obese patients could create a growth-enhancing microenvironment that alters gene expression in BRAF- and NRAS-mutated melanoma cell lines. SK-Mel-28 (BRAF-mutated) and Sk-Mel-147 (NRAS-mutated) cells were treated with pooled serum from 10 severely obese p...

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Bibliographic Details
Main Authors: Débora Mocellin, Letícia de Oliveira Souza Bratti, Adny Henrique Silva, Laura Sartori Assunção, Iara Fabricia Kretzer, Fabíola Branco Filippin-Monteiro
Format: Article
Language:English
Published: Universidade de São Paulo 2022-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Melanoma
Tumor progression
Inflammation
Morbidly obesity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100583&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100583&lng=en&tlng=en

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