Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis

Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis

Abstract Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics‐ and complex‐focused CRISPR screens, RUVBL1, the...

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Bibliographic Details
Main Authors: Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Advanced Science
Subjects:
EEF1A1
epigenetic
Ewing sarcoma
KAT5
MYC
RUVBL1
Online Access:https://doi.org/10.1002/advs.202206584

Internet

https://doi.org/10.1002/advs.202206584

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