Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice

Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice

Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) of...

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Bibliographic Details
Main Authors: Woohyun Kim, Jae Jin Shin, Yu Jin Jeong, Kyungdeok Kim, Jung Won Bae, Young Woo Noh, Seungjoon Lee, Woochul Choi, Se-Bum Paik, Min Whan Jung, Eunee Lee, Eunjoon Kim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
firing variability
IRSp53
medial prefrontal cortex
social behavior
BAIAP2
social deficit
Online Access:https://elifesciences.org/articles/74998

Internet

https://elifesciences.org/articles/74998

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