PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across from a published PBPK model for ethanol. Read acr...

Full description

Bibliographic Details
Main Authors: Rory P. Conolly, Harvey J. Clewell, Martha M. Moore, Jerry L. Campbell, Wanyun Cheng, R. Robinan Gentry
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
PBPK
MTD
genotoxicity
reduction
3-chloroallyl alcohol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1088011/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1088011/full

Similar Items