Earthworm-Derived Pore-Forming Toxin Lysenin and Screening of Its Inhibitors

Earthworm-Derived Pore-Forming Toxin Lysenin and Screening of Its Inhibitors

Lysenin is a pore-forming toxin from the coelomic fluid of earthworm Eisenia foetida. This protein specifically binds to sphingomyelin and induces erythrocyte lysis. Lysenin consists of 297 amino acids with a molecular weight of 41 kDa. We screened for cellular signal transduction inhibitors of low...

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Bibliographic Details
Main Authors: Neelanun Sukumwang, Kazuo Umezawa
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Toxins
Subjects:
Lysenin
Eisenia foetida
hemolysis
pore formation
sphingomyelin binding
Dalbergia latifolia
all-E-lutein
tyrosylproline anhydride
Online Access:http://www.mdpi.com/2072-6651/5/8/1392

Internet

http://www.mdpi.com/2072-6651/5/8/1392

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