Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7

Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins. U20 and U21 are predicted to be type I glycoproteins with extracytosolic immunoglobulin-like domains, but detailed...

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Bibliographic Details
Main Authors: Grant C. Weaver, Richa Arya, Christine L. Schneider, Amy W. Hudson, Lawrence J. Stern
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
human herpesvirus
major histocompatibility protein
immunoevasion
machine learning
structure prediction
MHC1b
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.864898/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.864898/full

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