Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required to demonstrate their removal to be below the...

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Bibliographic Details
Main Authors: Lisa Strasser, Giorgio Oliviero, Craig Jakes, Izabela Zaborowska, Patrick Floris, Meire Ribeiro da Silva, Florian Füssl, Sara Carillo, Jonathan Bones
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Data-independent acquisition
Host cell proteins
Critical quality attributes
Liquid chromatography-mass spectrometry
Monoclonal antibody
Chinese hamster ovary cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177921000502

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http://www.sciencedirect.com/science/article/pii/S2095177921000502

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