Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade

Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade

Antibodies targeting the co-inhibitory receptor programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1) have shown some activity in patients with metastatic triple-negative breast cancer (TNBC), especially in a recent Phase III clinical trial combining PD-L...

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Bibliographic Details
Main Authors: Karsten A. Pilones, Michal Hensler, Camille Daviaud, Jeffrey Kraynak, Jitka Fucikova, Lorenzo Galluzzi, Sandra Demaria, Silvia C. Formenti
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
c10orf54
cd8+ t cells
cyclophosphamide
4t1 cells
focal radiotherapy
immunological checkpoints
immunosurveillance
mdscs
myeloid cells
pd-1
tcga
vsir
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1830524

Internet

http://dx.doi.org/10.1080/2162402X.2020.1830524

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