Uracil-DNA glycosylase efficiency is modulated by substrate rigidity

Uracil-DNA glycosylase efficiency is modulated by substrate rigidity

Abstract Uracil DNA-glycosylase (UNG) is a DNA repair enzyme that removes the highly mutagenic uracil lesion from DNA using a base flipping mechanism. Although this enzyme has evolved to remove uracil from diverse sequence contexts, UNG excision efficiency depends on DNA sequence. To provide the mol...

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Bibliographic Details
Main Authors: Paul B. Orndorff, Souvik Poddar, Aerial M. Owens, Nikita Kumari, Bryan T. Ugaz, Samrat Amin, Wade D. Van Horn, Arjan van der Vaart, Marcia Levitus
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30620-0

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https://doi.org/10.1038/s41598-023-30620-0

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