AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment

AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment

Background/purpose: Cell pyroptosis and gingival inflammation have been implicated in periodontitis progression. Our previous study revealed that AR-A014418, a pharmacological inhibitor of glycogen synthase kinase-3β (GSK-3β), can enhance the migratory and osteogenic differentiation abilities of rat...

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Bibliographic Details
Main Authors: Huilan Xie, Yi Lin, Fang Fang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Journal of Dental Sciences
Subjects:
Dental pulp stem cell
Glycogen synthase kinase-3β inhibitor
Inflammation
Lipopolysaccharide
NLRP3 inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S1991790223000831

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http://www.sciencedirect.com/science/article/pii/S1991790223000831

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