DHODH and cancer: promising prospects to be explored

DHODH and cancer: promising prospects to be explored

Abstract Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis,...

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Bibliographic Details
Main Authors: Yue Zhou, Lei Tao, Xia Zhou, Zeping Zuo, Jin Gong, Xiaocong Liu, Yang Zhou, Chunqi Liu, Na Sang, Huan Liu, Jiao Zou, Kun Gou, Xiaowei Yang, Yinglan Zhao
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cancer & Metabolism
Subjects:
Cancer metabolism
Dihydroorotate dehydrogenase
DHODH inhibitors
De novo pyrimidine biosynthesis
Mitochondria
Online Access:https://doi.org/10.1186/s40170-021-00250-z

Internet

https://doi.org/10.1186/s40170-021-00250-z

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