DHODH and cancer: promising prospects to be explored
Abstract Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
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| Series: | Cancer & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40170-021-00250-z |
| _version_ | 1818646756299112448 |
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| author | Yue Zhou Lei Tao Xia Zhou Zeping Zuo Jin Gong Xiaocong Liu Yang Zhou Chunqi Liu Na Sang Huan Liu Jiao Zou Kun Gou Xiaowei Yang Yinglan Zhao |
| author_facet | Yue Zhou Lei Tao Xia Zhou Zeping Zuo Jin Gong Xiaocong Liu Yang Zhou Chunqi Liu Na Sang Huan Liu Jiao Zou Kun Gou Xiaowei Yang Yinglan Zhao |
| author_sort | Yue Zhou |
| collection | DOAJ |
| description | Abstract Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis, and is re-emerging as a validated therapeutic target for cancer therapy. In this review, we mainly unravel the biological function of DHODH in tumor progression, including its crucial role in de novo pyrimidine synthesis and mitochondrial respiratory chain in cancer cells. Moreover, various DHODH inhibitors developing in the past decades are also been displayed, and the specific mechanism between DHODH and its additional effects are illustrated. Collectively, we detailly discuss the association between DHODH and tumors in recent years here, and believe it will provide significant evidences and potential strategies for utilizing DHODH as a potential target in preclinical and clinical cancer therapies. |
| first_indexed | 2024-12-17T00:51:42Z |
| format | Article |
| id | doaj.art-d90b29d38bfe4ab6bc5b461aff25b67e |
| institution | Directory Open Access Journal |
| issn | 2049-3002 |
| language | English |
| last_indexed | 2024-12-17T00:51:42Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer & Metabolism |
| spelling | doaj.art-d90b29d38bfe4ab6bc5b461aff25b67e2022-12-21T22:09:45ZengBMCCancer & Metabolism2049-30022021-05-019112510.1186/s40170-021-00250-zDHODH and cancer: promising prospects to be exploredYue Zhou0Lei Tao1Xia Zhou2Zeping Zuo3Jin Gong4Xiaocong Liu5Yang Zhou6Chunqi Liu7Na Sang8Huan Liu9Jiao Zou10Kun Gou11Xiaowei Yang12Yinglan Zhao13State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyThe Laboratory of Anesthesiology and Critical Care Medicine, Translational Neuroscience Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyWest China School of Pharmacy, Sichuan UniversityState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyAbstract Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis, and is re-emerging as a validated therapeutic target for cancer therapy. In this review, we mainly unravel the biological function of DHODH in tumor progression, including its crucial role in de novo pyrimidine synthesis and mitochondrial respiratory chain in cancer cells. Moreover, various DHODH inhibitors developing in the past decades are also been displayed, and the specific mechanism between DHODH and its additional effects are illustrated. Collectively, we detailly discuss the association between DHODH and tumors in recent years here, and believe it will provide significant evidences and potential strategies for utilizing DHODH as a potential target in preclinical and clinical cancer therapies.https://doi.org/10.1186/s40170-021-00250-zCancer metabolismDihydroorotate dehydrogenaseDHODH inhibitorsDe novo pyrimidine biosynthesisMitochondria |
| spellingShingle | Yue Zhou Lei Tao Xia Zhou Zeping Zuo Jin Gong Xiaocong Liu Yang Zhou Chunqi Liu Na Sang Huan Liu Jiao Zou Kun Gou Xiaowei Yang Yinglan Zhao DHODH and cancer: promising prospects to be explored Cancer & Metabolism Cancer metabolism Dihydroorotate dehydrogenase DHODH inhibitors De novo pyrimidine biosynthesis Mitochondria |
| title | DHODH and cancer: promising prospects to be explored |
| title_full | DHODH and cancer: promising prospects to be explored |
| title_fullStr | DHODH and cancer: promising prospects to be explored |
| title_full_unstemmed | DHODH and cancer: promising prospects to be explored |
| title_short | DHODH and cancer: promising prospects to be explored |
| title_sort | dhodh and cancer promising prospects to be explored |
| topic | Cancer metabolism Dihydroorotate dehydrogenase DHODH inhibitors De novo pyrimidine biosynthesis Mitochondria |
| url | https://doi.org/10.1186/s40170-021-00250-z |
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