DHODH and cancer: promising prospects to be explored

DHODH and cancer: promising prospects to be explored

Abstract Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis,...

Full description

Bibliographic Details
Main Authors:	Yue Zhou, Lei Tao, Xia Zhou, Zeping Zuo, Jin Gong, Xiaocong Liu, Yang Zhou, Chunqi Liu, Na Sang, Huan Liu, Jiao Zou, Kun Gou, Xiaowei Yang, Yinglan Zhao
Format:	Article
Language:	English
Published:	BMC 2021-05-01
Series:	Cancer & Metabolism
Subjects:	Cancer metabolism Dihydroorotate dehydrogenase DHODH inhibitors De novo pyrimidine biosynthesis Mitochondria
Online Access:	https://doi.org/10.1186/s40170-021-00250-z

Similar Items

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors
by: CHE Xin, et al.
Published: (2024-03-01)

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode
by: Ting Zeng, et al.
Published: (2019-08-01)

The Novel <i>h</i>DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis
by: Giulia Sibille, et al.
Published: (2022-10-01)

Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
by: Shuntaro Miyake, et al.
Published: (2022-12-01)

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis
by: Fanxun Zeng, et al.
Published: (2021-03-01)

Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress
by: Bimala Malla, et al.
Published: (2022-01-01)

Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line
by: Amalia E, et al.
Published: (2022-07-01)

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
by: Rui Xiong, et al.
Published: (2020-08-01)

The Warburg effect modulates DHODH role in ferroptosis: a review
by: Alvan Amos, et al.
Published: (2023-05-01)

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro
by: Yu-Jin Kim, et al.
Published: (2020-07-01)

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro
by: Friedrich Hahn, et al.
Published: (2020-12-01)

New Insights into rice pyrimidine catabolic enzymes
by: Andrea J. Lopez, et al.
Published: (2023-02-01)

The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
by: Valentina Gaidano, et al.
Published: (2021-02-01)

Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
by: Wanyan Wang, et al.
Published: (2021-05-01)

Ferroptosis plays a novel role in nonalcoholic steatohepatitis pathogenesis
by: Fei Xiong, et al.
Published: (2022-12-01)

Editorial: Metabolic Rewiring in Leukemias
by: Nelida I. Noguera, et al.
Published: (2021-10-01)

Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification
by: Ziadoon Al-Akashi, et al.
Published: (2023-02-01)

The New Generation <i>h</i>DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses
by: Arianna Calistri, et al.
Published: (2021-08-01)

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses
by: Yucheng Zheng, et al.
Published: (2022-04-01)

A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage
by: Xiaowei Yang, et al.
Published: (2022-06-01)

The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria
by: Laura Martorano, et al.
Published: (2019-03-01)

A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
by: Scott Martin, et al.
Published: (2018-08-01)

The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line
by: Grzegorz Adamczuk, et al.
Published: (2021-09-01)

Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia
by: Tingyuan Yang, et al.
Published: (2023-10-01)

Recent approaches in the drug research and development of novel antimalarial drugs with new targets
by: Chinnappanna Naveen Kumar Reddy, et al.
Published: (2023-03-01)

A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression
by: Yongrui Hai, et al.
Published: (2024-04-01)

Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition
by: Alvan Amos, et al.
Published: (2023-02-01)

Vidofludimus inhibits porcine reproductive and respiratory syndrome virus infection by targeting dihydroorotate dehydrogenase
by: Yuanqi Yang, et al.
Published: (2023-12-01)

DHODH Inhibition Exerts Synergistic Therapeutic Effect with Cisplatin to Induce Ferroptosis in Cervical Cancer through Regulating mTOR Pathway
by: Mengying Jiang, et al.
Published: (2023-01-01)

Assessment of a novel variation in DHODH gene causing Miller syndrome: The first report in Chinese population
by: Kai Yang, et al.
Published: (2023-07-01)

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
by: Rebecca EK Mandt, et al.
Published: (2023-09-01)

Regioselective Synthesis of 5- and 3-Hydroxy-<i>N</i>-Aryl-1<i>H</i>-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase
by: Luka Vah, et al.
Published: (2022-07-01)

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
by: Salvatore Galati, et al.
Published: (2022-06-01)

17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy
by: Ying Tian, et al.
Published: (2023-06-01)

In vitro antiplasmodial activity, LC-MS analysis, and molecular docking studies of bioactive compounds from Tetrapleura tetraptera (Fabaceae) fruits
by: Sherif Hamidu, et al.
Published: (2023-11-01)

Modulating pyrimidine ribonucleotide levels for the treatment of cancer
by: Tanzina Mollick, et al.
Published: (2020-10-01)

Cloning and Characterization of Yak <i>DHODH</i> Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts
by: Hongmei Xu, et al.
Published: (2023-12-01)

A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor
by: Terri L. Morton, et al.
Published: (2023-04-01)

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
by: Maria Diedrichs-Möhring, et al.
Published: (2018-02-01)

Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer
by: Shengyuan Zhao, et al.
Published: (2023-12-01)