Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure

Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure

Abstract Background Particulate matter 2.5 (PM2.5) deposition in the lung’s alveolar capillary region (ACR) is significantly associated with respiratory disease development, yet the molecular mechanisms are not completely understood. Adverse responses that promote respiratory disease development inv...

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Bibliographic Details
Main Authors: Eva C. M. Vitucci, Alysha E. Simmons, Elizabeth M. Martin, Shaun D. McCullough
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Particle and Fibre Toxicology
Subjects:
Alveolar epithelial cells
Microvascular endothelial cells
Transcriptomics
Redox dysfunction
Tri-culture models
PM2.5
Online Access:https://doi.org/10.1186/s12989-024-00576-8

Internet

https://doi.org/10.1186/s12989-024-00576-8

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