Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload

Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload

Abstract An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressur...

Full description

Bibliographic Details
Main Authors: Jiong-Wei Wang, Magda S. C. Fontes, Xiaoyuan Wang, Suet Yen Chong, Elise L. Kessler, Ya-Nan Zhang, Judith J. de Haan, Fatih Arslan, Saskia C. A. de Jager, Leo Timmers, Toon A. B. van Veen, Carolyn S. P. Lam, Dominique P. V. de Kleijn
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09451-3

Internet

https://doi.org/10.1038/s41598-017-09451-3

Similar Items