Inhibition of astrocytic glutamine synthetase by lead is associated with a slowed clearance of hydrogen peroxide by the glutathione system

Inhibition of astrocytic glutamine synthetase by lead is associated with a slowed clearance of hydrogen peroxide by the glutathione system

Lead intoxication in humans is characterised by cognitive impairments, particularly in the domain of memory, where evidence indicates that glutamatergic neurotransmission may be impacted. Animal and cell culture studies have shown that lead decreases the expression and activity of glutamine syntheta...

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Bibliographic Details
Main Authors: Stephen Richard Robinson, Alan eLee, Glenda M. Bishop, Hania eCzerwinska, Ralf eDringen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Integrative Neuroscience
Subjects:
Astrocytes
Glutathione
Oxidative Stress
Glutamate
Toxicity
glutamine synthetase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00061/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00061/full

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