Further Extension of Lifespan by <i>Unc-43/CaMKII</i> and <i>Egl-8/PLCβ</i> Mutations in Germline-Deficient <i>Caenorhabditis elegans</i>

Further Extension of Lifespan by <i>Unc-43/CaMKII</i> and <i>Egl-8/PLCβ</i> Mutations in Germline-Deficient <i>Caenorhabditis elegans</i>

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) promotes longevity across species. In the nematode <i>Caenorhabditis elegans</i>, ablation of germline stem cells (GSCs) and activity changes of the conserved signaling mediators <i>unc-43/CaMKII</i> (ca...

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Bibliographic Details
Main Authors: Hildegard I. D. Mack, Laura G. Buck, Sonja Skalet, Jennifer Kremer, Hao Li, Elisabeth K. M. Mack
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
aging
stress resistance
insulin signaling
germline stem cells
RNA-seq
collagen
Online Access:https://www.mdpi.com/2073-4409/11/22/3527

Internet

https://www.mdpi.com/2073-4409/11/22/3527

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