Enhancement of human plasma glucosylceramide assay sensitivity using delipidized plasma

Enhancement of human plasma glucosylceramide assay sensitivity using delipidized plasma

Glucosylceramide (GL-1) level in human has been considered as a surrogate biomarker for enzyme replacement and substrate reduction therapies (ERT and SRT) for Gaucher and Fabry patients. Due to the high endogenous level of GL-1 in human plasma, it is difficult to achieve the analytical sensitivity o...

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Bibliographic Details
Main Authors: Kefei Zheng, Allena Ji, Lee Lee Chung, Kerry Culm-Merdek, Hanlan Liu, Susan Richards, Crystal Sung
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Glucosylceramide
Globotriaosylceramide
Liquid chromatography–tandem mass spectrometry (LC/MS/MS)
Delipidized plasma
Sensitivity
Standard addition method
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426916300520

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http://www.sciencedirect.com/science/article/pii/S2214426916300520

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