Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

BackgroundIdiopathic pulmonary fibrosis (IPF) is the result of multiple cycles of epithelial cell injury and fibroblast activation; currently, there is no clear etiology. Increasing evidence suggests that protein metabolism and amino acids play a crucial role in IPF, but the role of D-amino acids is...

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Bibliographic Details
Main Authors: Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
idiopathic pulmonary fibrosis
D-amino acid oxidase
triiodothyronine
anti-fibrotic axis
p53/p21 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1433186/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1433186/full

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