A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor. This study found that it efficiently activates the canonical Wnt signaling of bone marrow...

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Bibliographic Details
Main Authors: Bo Wang, Saima Khan, Pengtao Wang, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
CHIR99021
Wnt/β-catenin signaling
autophagy
integrated 3D printing
PCL scaffold
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.926622/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.926622/full

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