HPLC and LC–MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride

HPLC and LC–MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride

In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via liquid chromatography–mass spectroscopy (LC–M...

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Bibliographic Details
Main Authors: Pengyan Zhu, Xiaojing Shen, Xinting Wang, Xinlan Liu, Yingshuang Zhang, Ke Wang, Wenfen Gao, Xuanjun Wang, Wenjuan Yuan
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
sotalol hydrochloride (STHCl)
related substances
characterization
LC–MS/MS
NMR
MTT analysis
Online Access:https://www.mdpi.com/1420-3049/29/3/588

Internet

https://www.mdpi.com/1420-3049/29/3/588

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