LncRNA FOXD1-AS1 regulates pancreatic cancer stem cell properties and 5-FU resistance by regulating the miR-570-3p/SPP1 axis as a ceRNA

LncRNA FOXD1-AS1 regulates pancreatic cancer stem cell properties and 5-FU resistance by regulating the miR-570-3p/SPP1 axis as a ceRNA

Abstract Cancer stem cells (CSCs) play a pivotal role in the pathogenesis of human cancers. Previous studies have highlighted the role of long non-coding RNA (lncRNA) in modulating the stemness of CSCs. In our investigation, we identified an upregulation of lncRNA FOXD1-AS1 in CSCs. The enforced exp...

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Bibliographic Details
Main Authors: Liu Ouyang, Min-min Sun, Ping-sheng Zhou, Yi-wei Ren, Xin-yu Liu, Wan-ying Wei, Zhen-shun Song, Kai Lu, Li-xue Yang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Pancreatic cancer
Cancer stem cell
lncRNA FOXD1-AS1
N6-methyladenosine, 5-FU
Online Access:https://doi.org/10.1186/s12935-023-03181-5

Internet

https://doi.org/10.1186/s12935-023-03181-5

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